Dr. Keisuke Ishihara from University of Pittsburgh
Our lab takes a synthetic approach to study how cells form tissues. “Synthetic” embodies the experimental creation of states of physical organization and gene expression that push a multicellular system to all possible extremes. The synthetic approach allows us to discover novel regulatory molecules, dormant genetic programs, and general physical principles, which we will critically evaluate as next generation strategies for organ engineering. In this seminar, we will cover our recent work 1 , in which we quantitatively captured 3D tissue morphogenesis through imaging, computation, and molecular profiling. In the future, we are interested in expanding such an approach to develop genetic and chemical tools to engineer in vitro tissues such as human brain organoids and cardiac organoids.
Reference: Ishihara, K., Mukherjee, A., Gromberg, E., Brugués, J., Tanaka, E.M., Jülicher, F., 2023. Topological morphogenesis of neuroepithelial organoids. Nat. Phys. 1–7. https://doi.org/10.1038/s41567-022-01822-6
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