Dr. Huijing Du from University of Nebraska, Lincoln
Multiscale modeling is being increasingly utilized to enable more comprehensive analysis of biological processes in ways that are relevant to experiments. A new hybrid framework is developed that combines the discrete stochastic Subcellular Element Model for individual cellular activity and continuum partial differential equations of extracellular biomolecule signaling and hydrodynamical mechanism, in order to set up an approach spanning multiple levels of biophysical reality. Our findings show how a modeling approach coupling biologically relevant scales can provide new insights into the complex biological problems connected to bacterial swarming and epidermal tissue regeneration.
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